Offline Leak Check In Vacuum Chamber Machine

USA Pack Machines LLC provides an Offline Leak Check in Vacuum Chamber Machine designed for 1 ml to 3 ml Respules and 5 ml, 10 ml, 15 ml, 20 ml WFIs (Water for Injection) for SVP (Small Volume Parenterals) applications.

Offline Leak Check In Vacuum Chamber Machine

Offline Leak Check in Vacuum Chamber Machine

USA Pack Machines LLC provides advanced Offline Leak Check in Vacuum Chamber Machines designed for precise testing of 1 ml to 3 ml Respules and 5 ml, 10 ml, 15 ml, 20 ml WFIs (Water for Injection) used in SVPs (Small Volume Parenterals). Engineered for accuracy and reliability, this machine ensures that only leak-free, high-quality pharmaceutical products reach
the market.

How Does It Work?

The testing process begins when Respules or WFIs are placed into the machine’s vacuum chamber. Once the chamber is sealed, the system removes air to create a vacuum, simulating real-world pressure conditions where leaks may occur. During this stage, the machine carefully monitors chamber pressure. If the pressure rises or fails to stabilize, it indicates that air is seeping in through a leak in one or more containers.

At the end of the cycle, the vacuum is released, returning the chamber to atmospheric pressure. The operator then separates the defective containers identified during the test. Leak-free units proceed safely to the next stage of production, guaranteeing that only intact and secure products are delivered to patients. This reliable process is critical in upholding pharmaceutical safety and regulatory standards.

Why Choose USA Pack Machines LLC?

USA Pack Machines LLC is a trusted partner for pharmaceutical companies seeking cutting-edge leak detection solutions. Our dedicated engineering team designs and develops innovative systems that meet both customer-specific requirements and strict industry regulations. With a strong commitment to research and development, we continually introduce technologies that help clients enhance efficiency, reduce waste, and maintain product integrity.

In addition, we provide robust after-sales service, ensuring long-term machine reliability and uninterrupted production. Our focus on engineering excellence and customer satisfaction allows us to deliver world-class solutions that align with evolving industry demands.

Serving Global Pharma Needs

From IV Bottle/IV Bag packaging lines (Large Volume Parenterals) to Respules and WFI packaging lines (Small Volume Parenterals), USA Pack Machines LLC delivers tailored solutions that empower startups, SMEs, and large enterprises to thrive in a competitive market.

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# Model Output Speed
1 UPML-VLC 4000 Respules/Cycle (Depends on the product & tray size)

The chamber mainly consists of:

  • Basic Structure
  • Vacuum Chamber with Lid
  • Main Motor with Gear Drive
  • Vacuum Pump, 750 LPM
  • Loading Trays for WFI Respules/Cassettes
  • Electrical Control Panel
  • Tilting Device with Limit Switch
  • The machine is manufactured or developed per GMP standards.
  • The main structure is made of MS, coated with colour & the vacuum chamber is made of SS 304.
  • Equipped with a Vacuum pump of 750 LPM capacity.
  • Suitable for WFI Respules/Cassettes.
  • Rigid vibration-free construction for trouble-free performance.
  • Trouble-free operation. Can be handled by a single person.
  • Mobile tray facility. Can be easily loaded into rows.
  • Heavy & rigid structure of vacuum chamber.
  • Specially designed tilting device with limit switch & sensors.
  • Drain valve for removing the liquid.
  • Equipped with genuine vacuum gauges.
  • Specially designed lid with locking hinges & gasket.
  • The WFI Respules/Cassettes are manually loaded on the trays.
  • Loaded trays are then kept in the vacuum chamber in rows.
  • The lid is pressed & closed with specially designed hinges.
  • The control panel is set to ON mode.
  • The vacuum pump is then started.
  • The vacuum is set to 600 mm/Hg & the timer is settable.
  • The limit switch gets activated & the tilting of the chamber takes place by means of a sensor.
  • The tilting is completed at 180 degrees.
  • As per the set time, the vacuum chamber again rotates & comes to the home position.
  • The vacuum inside the chamber slowly gets reduced.
  • The lid is opened to check the WFI Respules/Cassettes.
  • The faulty, damaged or leaked WFI Respules/Cassettes are removed from the tray.
  • The OK WFI Respules/Cassettes are collected & conveyed for the process.
Model UPML–VLC
Product Respules & WFIs (Water for Injections)
Product Size 1 ml to 3 ml Respules & 5 ml, 10 ml, 15 ml, 20 ml WFIs
Output/Cycle 4000 Respules/Cycle (Depends on the product & tray size)
Working Height Standard
Main Motor & Gear Drive 1 HP / 35:1 Ratio
Vacuum Pump 750 LPM
Motor for Vacuum Pump 1 HP, 1400 RPM
Power Supply Three Phase +N +E / 415 V AC / 50 Hz
Power Consumption About 2.5 HP
Tray Size Approx. 775 mm L x 555 mm W x 90 mm H
Panel Box Dimension 410 mm L x 450 mm W x 1260 mm H
Dimensions Approx. 2500 mm L X 1000 mm W X 1355 mm H
Net Weight Approx. 650 Kg

 

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